Journal: BMJ Open Ophthalmology
Article Title: Novel electroretinography devices to detect hydroxychloroquine retinopathy: study protocol for a diagnostic accuracy and feasibility study
doi: 10.1136/bmjophth-2024-001898
Figure Lengend Snippet: Current recommended flow diagram for screening of patients on HCQ or CQ. Reproduced from the RCOphth HCQ and CQ screening guidelines. Abbreviations: CQ, chloroquine; eGFR, estimated glomerular filtration rate; FAF, fundus autofluorescence; HCQ, hydroxychloroquine; HVF, Humphrey automated visual field; mfERG, multifocal electroretinography; SD-OCT, spectral-domain optical coherence tomography.
Article Snippet: Three groups of 35 participants on HCQ, categorised by HCQ retinopathy (definite, possible and no retinopathy), and 35 healthy control participants, recruited by consecutive sampling, will have full field and multifocal ERG index tests, delivered using skin-contact electrodes by two devices—RETEval full-field and UTAS multifocal ERG, both manufactured by LKC Technologies (Gaithersburg, Maryland, USA), compared with spectral-domain optical coherence tomography and autofluorescence reference tests graded by two masked, independent retinal specialists.
Techniques: Filtration, Tomography